Somatic cell interventions will not have unintended effects on the germ-line of recipients….

Some proponents, through application of the principle of double effect have answered the problem of somatic cell interventions designed and intended only to affect the somatic cells, which unintentionally cause alterations to the germ-line. Marc Lappe states that “Germ-line engineering as a direct attempt to change the genotype of future generations cannot ethically be justified. However, when such changes arise as an indirect and otherwise unavoidable consequence of an approved form of somatic cell engineering, they are morally acceptable. The first objection relates to the issue of intention and the unintended consequences of the interventions. Two people, both suffering the same condition attempt to acquire somatic cell intervention to remedy the condition they possess. The intention of the first person is to have the therapy in order to correct the condition, as it is present in them. The second person however knows that there is risk that the procedure will have an effect on their germ-line and this is the major reason for them wanting to undergo the procedure. While they want the condition corrected in them, the major intention in undergoing the procedure is to alter the germ-line so that any progeny will not have to suffer the condition in their life. It seems under the principle of double effect that the first person should be accepted for the therapy while the second should be rejected on the ground that he is more concerned about the effects of the condition on his offspring then on himself. As Moseley suggests, “this would seem to be a morally questionable criterion for a physician to use in deciding whether to proceed with genetic therapy. It is also troubling that all that the second person needs to in order to procure the procedure for them is to lie about their primary intention for wanting to the intervention. Having a situation where people are forced to lie or omit information in order to receive treatment cannot be one that can be said to be good medical practice.